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Innovation Tracking Factbook 2018: An Assessment of the Pharmaceutical Pipeline
SKU ID : CBR-13748402 | Publishing Date : 14-Dec-2018 | No. of pages : 57
Detailed TOC of Innovation Tracking Factbook 2018: An Assessment of the Pharmaceutical Pipeline
1 Table of Contents1 Table of Contents 3
1.1 List of Tables 4
1.2 List of Figures 4
2 Introduction 6
2.1 Increasing Cost of Drug Development 9
2.2 Most Drugs Fail to Recuperate R&D Costs 10
2.3 Contracting Life Cycles for Approved Products 11
2.4 The Case for First-in-Class Pharmaceutical Innovation 13
2.5 Status of Innovation in Rare Diseases 14
2.6 Conclusion 16
3 Assessment of Pharmaceutical Industry Pipeline 17
3.1 Pipeline and Clinical Trials Landscape by Therapy Area 18
3.2 Pipeline by Stage of Development 24
3.3 Pipeline by Molecule Type 26
3.4 Key Therapy Areas by Indication 30
3.4.1 Oncology 30
3.4.2 Infectious Diseases 32
3.4.3 Central Nervous System 34
3.4.4 Immunology 36
3.5 Conclusion 38
4 Assessment of Innovation in the Pharmaceutical Industry Pipeline 39
4.1 First-in-Class Innovation by Stage of Development 42
4.2 Key Therapy Areas by Indication 43
4.2.1 Oncology 43
4.2.2 Infectious Diseases 46
4.2.3 Central Nervous System 49
4.2.4 Immunology 52
4.3 Conclusion 54
5 Appendix 55
5.1 References 55
5.2 Abbreviations 56
5.3 Contact Us 56
5.4 Disclaimer 57
List of Figures, Tables and Charts Available in Innovation Tracking Factbook 2018: An Assessment of the Pharmaceutical Pipeline
1.1 List of TablesTable 1: Trends in Clinical Trial Protocol Complexity, 2001-2015 9
Table 2: Pipeline Products by Therapy Area, 2015-Q3 2018 20
Table 3: Number of Clinical Trials Initiated by Therapy Area, 2007-2017 23
Table 4: Pipeline Products by Therapy Area and Stage of Development, Q3 2018 26
Table 5: Pipeline Products by Therapy Area and Molecule Type, Q3 2018 29
Table 6: First-in-Class Pipeline Products by Therapy Area, Q1 2015-Q3 2018 41
Table 7: First-in-Class Oncology Pipeline Products by Indication, Q1 2015-Q3 2018 45
Table 8: First-in-Class Infectious Diseases Pipeline Products by Indication, Q1 2015-Q3 2018 48
Table 9: First-in-Class Central Nervous System Disorder Pipeline Products by Indication, Q1 2015-Q3 2018 51
Table 10: First-in-Class Immunology Pipeline Products by Indication, Q1 2015-Q3 2018 541.2 List of Figures
Figure 1: US Life Expectancy by Sex, 1950-2017 6
Figure 2: FDA Approvals, 1993-2018 8
Figure 3: Average Cost of Developing a Novel Drug ($m), 1970-2016 9
Figure 4: Projected R&D Returns (%), 2010-2017 10
Figure 5: Drivers of Shortened Pharmaceutical Product Life Cycles, 1970-2011 11
Figure 6: Patent Challenges by Generic Companies 12
Figure 7: FDA Approvals by Innovation Status, 1987-2017 13
Figure 8: Average Sales of First-in-Class and Non-First-in-Class Products After Launch ($m), 2006-2014 14
Figure 9: Average Projected Sales of First-in-Class and Non-First-in-Class Products Launched in 2015 ($m), 2016-2022 14
Figure 10: FDA Orphan Drug Approvals, 1983-2017 15
Figure 11: Pipeline Products by Stage and Molecule Type, Q3 2018 17
Figure 12: Pipeline Products by Therapy Area, Q3 2018 18
Figure 13: Overall Pipeline, Number of Products and Pipeline Growth by Therapy Area, Q1 2015-Q3 2018 19
Figure 14: Number of Clinical Trials Initiated, 2007-2017 21
Figure 15: Number of Clinical Trials Initiated by Therapy Area, 2007-2017 22
Figure 16: Pipeline Products by Therapy Area and Stage of Development (%), Q3 2018 24
Figure 17: Pipeline Products by Therapy Area and Stage of Development, Q3 2018 25
Figure 18: Pipeline Products by Therapy Area and Molecule Type, Q3 2018 27
Figure 19: Pipeline Products by Therapy Area and Molecule Type, Q3 2018 28
Figure 20: Oncology Pipeline Products by Indication, Q3 2018 30
Figure 21: Oncology Pipeline, Number of Products by Indication, Q1 2015-Q3 2018 31
Figure 22: Infectious Disease Pipeline, Number of Products by Indication, Q3 2018 32
Figure 23: Infectious Disease Pipeline, Number of Products and Pipeline Growth by Indication, Q1 2015-Q3 2018 33
Figure 24: Central Nervous System Pipeline, Number of Products by Indication, Q3 2018 34
Figure 25: Central Nervous System Pipeline, Number of Products and Pipeline Growth by Indication, Q1 2015-Q3 2018 35
Figure 26: Immunology Pipeline, Number of Products by Indication, Q3 2018 36
Figure 27: Immunology Pipeline, Number of Products and Pipeline Growth by Indication, Q1 2015-Q3 2018 37
Figure 28: Pipeline Products by Therapy Area and Proportion of Established and First-in-Class Products, Q3 2018 39
Figure 29: First-in-Class Pipeline, Number of Products and Pipeline Growth by Therapy Area, Q1 2015-Q3 2018 40
Figure 30: First-in-class Pipeline Products by Therapy Area and Stage of Development, Q3 2018 42
Figure 31: First-in-Class Oncology Pipeline Products by Indication, Q3 2018 43
Figure 32: First-in-Class Oncology Pipeline, Number of Products and Pipeline Growth by Indication, Q1 2015-Q3 2018 44
Figure 33: First-in-Class Infectious-Diseases Pipeline Products by Indication, Q3 2018 46
Figure 34: First-in-Class Infectious Disease Pipeline, Number of Products and Pipeline Growth by Indication, Q1 2015-Q3 2018 47
Figure 35: First-in-Class Central Nervous System Disorder Pipeline Products by Indication, Q3 2018 49
Figure 36: First-in-Class Central Nervous System Disorder Pipeline, Number of Products and Pipeline Growth by Indication, Q1 2015-Q3 2018 50
Figure 37: First-in-Class Immunology Disorder Pipeline, Number of Products by Indication, Q3 2018 52
Figure 38: First-in-Class Immunology Pipeline, Number of Products and Pipeline Growth by Indication, Q1 2015-Q3 2018 53
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