Table of Contents PART 01: EXECUTIVE SUMMARY PART 02: SCOPE OF THE REPORT PART 03: RESEARCH METHODOLOGY PART 04: INTRODUCTION • Market outline PART 05: MARKET LANDSCAPE • Market ecosystem • Market characteristics • Market segmentation analysis PART 06: MARKET SIZING • Market definition • Market sizing 2017 • Market size and forecast 2017-2022 PART 07: FIVE FORCES ANALYSIS • Bargaining power of buyers • Bargaining power of suppliers • Threat of new entrants • Threat of substitutes • Threat of rivalry • Market condition PART 08: MARKET SEGMENTATION BY PRODUCT • Segmentation by product • Comparison by product • Global bone grafts market • Global BMPs market • Global BMAC market • Global others market • Market opportunity by product PART 09: CUSTOMER LANDSCAPE PART 10: REGIONAL LANDSCAPE • Geographical segmentation • Regional comparison • Spine biologics market in Americas • Spine biologics market in EMEA • Spine biologics market in APAC • Market opportunity PART 11: DECISION FRAMEWORK PART 12: DRIVERS AND CHALLENGES • Market drivers • Market challenges PART 13: MARKET TRENDS • Growing strategic alliances • Increasing cases of lumbar fusion • Increasing adoption of minimally invasive surgery PART 14: VENDOR LANDSCAPE • Overview • Landscape disruption • Vendors covered • Vendor classification • Market positioning of vendors • Alphatec Spine • Globus Medical • Medtronic • NuVasive PART 15: APPENDIX • List of abbreviations List of Exhibits Exhibit 01: Parent market Exhibit 02: Global spine biologics market 2017 Exhibit 03: Market characteristics Exhibit 04: Market segments Exhibit 05: Market definition: Inclusions and exclusions checklist Exhibit 06: Market size 2017 Exhibit 07: Validation techniques employed for market sizing 2017 Exhibit 08: Global spine biologics market size and forecast 2017-2022 ($ millions) Exhibit 09: Global spine biologics market: Year-over-year growth 2018-2022 (%) Exhibit 10: Five forces analysis 2017 Exhibit 11: Five forces analysis 2022 Exhibit 12: Bargaining power of buyers Exhibit 13: Bargaining power of suppliers Exhibit 14: Threat of new entrants Exhibit 15: Threat of substitutes Exhibit 16: Threat of rivalry Exhibit 17: Market condition - Five forces 2017 Exhibit 18: Spine biologics product market share 2017-2022 (%) Exhibit 19: Comparison by product Exhibit 20: Global bone grafts market 2017-2022 ($ millions) Exhibit 21: Global bone grafts market: YOY growth 2018-2022 (%) Exhibit 22: Global BMPs market 2017-2022 ($ millions) Exhibit 23: Global BMPs market: YoY growth 2018-2022 (%) Exhibit 24: Global BMAC market 2017-2022 ($ millions) Exhibit 25: Global BMAC market: YoY growth 2018-2022 (%) Exhibit 26: Global others market 2017-2022 ($ millions) Exhibit 27: Global others market: YoY growth 2018-2022 (%) Exhibit 28: Market opportunity by product Exhibit 29: Customer landscape Exhibit 30: Global spine biologics market share by geography 2017-2022 (%) Exhibit 31: Regional comparison Exhibit 32: Spine biologics market in Americas 2017-2022 ($ millions) Exhibit 33: Spine biologics market in Americas: YoY growth 2018-2022 (%) Exhibit 34: Top three countries in Americas Exhibit 35: Spine biologics market in EMEA 2017-2022 ($ millions) Exhibit 36: Spine biologics market in EMEA: YoY growth 2018-2022 (%) Exhibit 37: Top three countries in EMEA Exhibit 38: Spine biologics market in APAC 2017-2022 ($ millions) Exhibit 39: Spine biologics market in APAC: YoY growth 2018-2022 (%) Exhibit 40: Top three countries in APAC Exhibit 41: Market opportunity Exhibit 42: World population by age group 2015-2050 (in millions) Exhibit 43: Benefits of minimally invasive technique Exhibit 44: Vendor landscape Exhibit 45: Landscape disruption Exhibit 46: Vendors covered Exhibit 47: Vendor classification Exhibit 48: Market positioning of vendors Exhibit 49: Alphatec Spine: Overview Exhibit 50: Alphatec Spine: Business segments Exhibit 51: Alphatec Spine: Organizational developments Exhibit 52: Alphatec Spine: Geographic focus Exhibit 53: Alphatec Spine: Segment focus Exhibit 54: Alphatec Spine: Key offerings Exhibit 55: Alphatec Spine: Key customers Exhibit 56: Globus Medical: Overview Exhibit 57: Globus Medical: Business segments Exhibit 58: Globus Medical: Organizational developments Exhibit 59: Globus Medical: Geographic focus Exhibit 60: Globus Medical: Segment focus Exhibit 61: Globus Medical Key offerings Exhibit 62: Globus Medical: Key customers Exhibit 63: Medtronic: Overview Exhibit 64: Medtronic: Business segments Exhibit 65: Medtronic: Organizational developments Exhibit 66: Medtronic: Geographic focus Exhibit 67: Medtronic: Segment focus Exhibit 68: Medtronic: Key offerings Exhibit 69: Medtronic: Key customers Exhibit 70: NuVasive: Overview Exhibit 71: NuVasive: Business segments Exhibit 72: NuVasive: Organizational developments Exhibit 73: NuVasive: Geographic focus Exhibit 74: NuVasive: Segment focus Exhibit 75: NuVasive: Key offerings Exhibit 76: NuVasive: Key customers

Alphatec Spine, Globus Medical, Medtronic, NuVasive, AlloSource, AMENDIA, ChoiceSpine, DePuy Synthes, Exactech, and Harvest Technologies.