TABLE OF CONTENT 1 EXECUTIVE SUMMARY 1.1 OVERVIEW 12 1.1.1 MARKET SYNOPSIS 12 2 MARKET INTRODUCTION 2.1 SCOPE OF THE STUDY 13 2.2 RESEARCH OBJECTIVE 13 2.3 LIST OF ASSUMPTIONS 13 3 RESEARCH METHODOLOGY 3.1 OVERVIEW 15 3.2 DATA MINING 15 3.3 SECONDARY RESEARCH 16 3.4 PRIMARY RESEARCH 17 3.4.1 PRIMARY INTERVIEWS AND INFORMATION GATHERING PROCESS 17 3.4.2 BREAKDOWN OF PRIMARY RESPONDENTS 18 3.5 FORECASTING TECHNIQUES 18 3.6 RESEARCH METHODOLOGY FOR MARKET SIZE ESTIMATION 19 3.6.1 BOTTOM-UP APPROACH 20 3.6.2 TOP-DOWN APPROACH 21 3.7 DATA TRIANGULATION 21 3.8 VALIDATION 21 4 MARKET DYNAMICS 4.1 OVERVIEW 22 4.2 DRIVERS 23 4.2.1 RISING GERIATRIC POPULATION WITH VISION PROBLEMS 23 4.2.2 RETINITIS PIGMENTOSA DISEASES 23 4.2.3 PRODUCT LAUNCH AND TECHNOLOGICAL ADVANCEMENT 23 4.3 RESTRAINTS 24 4.3.1 SURGICAL COMPLICATIONS OF ARTIFICIAL IMPLANTS 24 4.3.2 AVAILABILITY OF ALTERNATIVE TREATMENT METHODS 24 4.4 OPPORTUNITIES 25 4.4.1 DEVELOPMENT OF INNOVATIVE PRODUCTS 25 4.5 PREVALENCE OF DISEASES 25 5 MARKET FACTOR ANALYSIS 5.1 VALUE CHAIN ANALYSIS 26 5.1.1 R&D AND DESIGNING 27 5.1.2 MANUFACTURING 27 5.1.3 DISTRIBUTION 27 5.1.4 MARKETING AND SALES 27 5.2 PORTER’S FIVE FORCES MODEL 28 5.2.1 BARGAINING POWER OF SUPPLIERS 28 5.2.2 BARGAINING POWER OF BUYERS 28 5.2.3 THREAT OF NEW ENTRANTS 29 5.2.4 THREAT OF SUBSTITUTES 29 5.2.5 INTENSITY OF RIVALRY 29 6 GLOBAL ARTIFICIAL RETINA MARKET, BY PRODUCT 6.1 OVERVIEW 30 6.2 EPIRETINAL IMPLANTS 31 6.3 SUBRETINAL IMPLANTS 31 6.4 SUPRACHOROIDAL IMPLANTS 32 7 GLOBAL ARTIFICIAL RETINA MARKET, BY INDICATION 7.1 OVERVIEW 33 7.2 AGE-RELATED MACULAR DEGENERATION (AMD) 34 7.3 RETINITIS PIGMENTOSA 34 8 GLOBAL ARTIFICIAL RETINA MARKET, BY END USER 8.1 OVERVIEW 36 8.2 OPHTHALMIC CENTERS 37 8.3 HOSPITALS 37 9 GLOBAL ARTIFICIAL RETINA MARKET, BY REGION 9.1 OVERVIEW 38 9.2 AMERICAS 39 9.2.1 NORTH AMERICA 41 9.2.2 LATIN AMERICA 44 9.3 EUROPE 45 9.3.1 WESTERN EUROPE 47 9.3.2 EASTERN EUROPE 54 9.4 ASIA-PACIFIC 56 9.4.1 JAPAN 58 9.4.2 CHINA 59 9.4.3 INDIA 60 9.4.4 AUSTRALIA 61 9.4.5 SOUTH KOREA 62 9.4.6 REST OF ASIA-PACIFIC 63 9.5 MIDDLE EAST & AFRICA 65 9.5.1 MIDDLE EAST 67 9.5.2 AFRICA 68 10 COMPETITIVE LANDSCAPE: GLOBAL ARTIFICIAL RETINA MARKET 10.1 OVERVIEW 70 10.2 TOP PLAYERS ANALYSIS 70 10.3 COMPETITOR DASHBOARD 71 10.4 COMPETITIVE BENCHMARKING 71 10.5 MAJOR GROWTH STRATEGY IN THE GLOBAL ARTIFICIAL RETINA MARKET 72 10.6 KEY DEVELOPMENTS AND GROWTH STRATEGIES 72 10.6.1 AGREEMENT 72 11 COMPANY PROFILES 11.1 SECOND SIGHT 73 11.1.1 COMPANY OVERVIEW 73 11.1.2 FINANCIAL OVERVIEW 73 11.1.3 PRODUCTS/SERVICES OFFERED 74 11.1.4 KEY DEVELOPMENTS 74 11.1.5 SWOT ANALYSIS 75 11.1.6 KEY STRATEGIES 75 11.2 PIXIUM VISION 76 11.2.1 COMPANY OVERVIEW 76 11.2.2 FINANCIAL OVERVIEW 76 11.2.3 PRODUCTS/SERVICES OFFERED 76 11.2.4 KEY DEVELOPMENTS 76 11.2.5 SWOT ANALYSIS 77 11.2.6 KEY STRATEGIES 77 11.3 OPTOBIONICS 78 11.3.1 COMPANY OVERVIEW 78 11.3.2 FINANCIAL OVERVIEW 78 11.3.3 PRODUCTS/SERVICES OFFERED 78 11.3.4 KEY DEVELOPMENTS 78 11.3.5 SWOT ANALYSIS 79 11.3.6 KEY STRATEGIES 79 12 APPENDIX 12.1 REFERENCES 80 12.2 RELATED REPORTS 81

LIST OF TABLES TABLE 1 LIST OF ASSUMPTIONS 13 TABLE 2 PREVALENCE OF DISEASES 25 TABLE 3 GLOBAL ARTIFICIAL RETINA MARKET, BY TYPE 2016-2025 (USD THOUSAND) 30 TABLE 4 GLOBAL ARTIFICIAL RETINA MARKET, FOR EPIRETINAL IMPLANTS, BY REGION 2016-2025 (USD THOUSAND) 31 TABLE 5 GLOBAL ARTIFICIAL RETINA MARKET, FOR SUBRETINAL IMPLANTS, BY REGION 2016-2025 (USD THOUSAND) 31 TABLE 6 GLOBAL ARTIFICIAL RETINA MARKET, FOR SUPRACHOROIDAL IMPLANTS, BY REGION 2016-2025 (USD THOUSAND) 32 TABLE 7 GLOBAL ARTIFICIAL RETINA MARKET, BY INDICATION 2016-2025 (USD THOUSAND) 33 TABLE 8 GLOBAL ARTIFICIAL RETINA MARKET, FOR AGE-RELATED MACULAR DEGENERATION (AMD), BY REGION 2016-2025 (USD THOUSAND) 34 TABLE 9 GLOBAL ARTIFICIAL RETINA MARKET, FOR RETINITIS PIGMENTOSA, BY REGION 2016-2025 (USD THOUSAND) 35 TABLE 10 GLOBAL ARTIFICIAL RETINA MARKET, BY END USER 2016-2025 (USD THOUSAND) 36 TABLE 11 GLOBAL ARTIFICIAL RETINA MARKET, FOR OPHTHALMIC CENTERS, BY REGION 2016-2025 (USD THOUSAND) 37 TABLE 12 GLOBAL ARTIFICIAL RETINA MARKET, FOR HOSPITALS, BY REGION 2016-2025 (USD THOUSAND) 37 TABLE 13 GLOBAL: ARTIFICIAL RETINA MARKET, BY REGION, 2016–2025 (USD THOUSAND) 38 TABLE 14 AMERICAS: ARTIFICIAL RETINA MARKET, BY REGION, 2016–2025 (USD THOUSAND) 39 TABLE 15 AMERICAS: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 40 TABLE 16 AMERICAS: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 40 TABLE 17 AMERICAS: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 40 TABLE 18 NORTH AMERICA: ARTIFICIAL RETINA MARKET, BY COUNTRY, 2016–2025 (USD THOUSAND) 41 TABLE 19 NORTH AMERICA: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 41 TABLE 20 NORTH AMERICA: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 41 TABLE 21 NORTH AMERICA: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 42 TABLE 22 US: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 42 TABLE 23 US: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 42 TABLE 24 US: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 43 TABLE 25 CANADA: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 43 TABLE 26 CANADA: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 43 TABLE 27 CANADA: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 44 TABLE 28 LATIN AMERICA: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 44 TABLE 29 LATIN AMERICA: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 44 TABLE 30 LATIN AMERICA: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 45 TABLE 31 EUROPE ARTIFICIAL RETINA MARKET, BY REGION 2016-2025 (USD THOUSAND) 46 TABLE 32 EUROPE: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 46 TABLE 33 EUROPE: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 46 TABLE 34 EUROPE: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 47 TABLE 35 WESTERN EUROPE ARTIFICIAL RETINA MARKET, BY COUNTRY 2016-2025 (USD THOUSAND) 47 TABLE 36 WESTERN EUROPE: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 47 TABLE 37 WESTERN EUROPE: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 48 TABLE 38 WESTERN EUROPE: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 48 TABLE 39 GERMANY: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 48 TABLE 40 GERMANY: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 49 TABLE 41 GERMANY: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 49 TABLE 42 FRANCE: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 49 TABLE 43 FRANCE: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 50 TABLE 44 FRANCE: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 50 TABLE 45 UK: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 50 TABLE 46 UK: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 51 TABLE 47 UK: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 51 TABLE 48 ITALY: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 51 TABLE 49 ITALY: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 52 TABLE 50 ITALY: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 52 TABLE 51 SPAIN: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 52 TABLE 52 SPAIN: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 53 TABLE 53 SPAIN: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 53 TABLE 54 REST OF WESTERN EUROPE: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 53 TABLE 55 REST OF WESTERN EUROPE: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 54 TABLE 56 REST OF WESTERN EUROPE: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 54 TABLE 57 EASTERN EUROPE: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 54 TABLE 58 EASTERN EUROPE: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 55 TABLE 59 EASTERN EUROPE: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 55 TABLE 60 ASIA-PACIFIC: ARTIFICIAL RETINA MARKET, BY COUNTRY, 2016–2025 (USD THOUSAND) 56 TABLE 61 ASIA-PACIFIC: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 57 TABLE 62 ASIA-PACIFIC: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 57 TABLE 63 ASIA-PACIFIC: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 57 TABLE 64 JAPAN: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 58 TABLE 65 JAPAN: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 58 TABLE 66 JAPAN: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 58 TABLE 67 CHINA: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 59 TABLE 68 CHINA: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 59 TABLE 69 CHINA: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 60 TABLE 70 INDIA: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 60 TABLE 71 INDIA: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 60 TABLE 72 INDIA: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 61 TABLE 73 AUSTRALIA: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 61 TABLE 74 AUSTRALIA: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 62 TABLE 75 AUSTRALIA: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 62 TABLE 76 SOUTH KOREA: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 62 TABLE 77 SOUTH KOREA: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 63 TABLE 78 SOUTH KOREA: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 63 TABLE 79 REST OF ASIA-PACIFIC: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 63 TABLE 80 REST OF ASIA-PACIFIC: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 64 TABLE 81 REST OF ASIA-PACIFIC: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 64 TABLE 82 MIDDLE EAST & AFRICA: ARTIFICIAL RETINA MARKET, BY COUNTRY, 2016–2025 (USD THOUSAND) 66 TABLE 83 MIDDLE EAST & AFRICA: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 66 TABLE 84 MIDDLE EAST & AFRICA: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 66 TABLE 85 MIDDLE EAST & AFRICA: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 67 TABLE 86 MIDDLE EAST: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 67 TABLE 87 MIDDLE EAST: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 67 TABLE 88 MIDDLE EAST: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 68 TABLE 89 AFRICA: ARTIFICIAL RETINA MARKET, BY PRODUCT, 2016–2025 (USD THOUSAND) 68 TABLE 90 AFRICA: ARTIFICIAL RETINA MARKET, BY INDICATION, 2016–2025 (USD THOUSAND) 68 TABLE 91 AFRICA: ARTIFICIAL RETINA MARKET, BY END USER, 2016–2025 (USD THOUSAND) 69 TABLE 92 AGREEMENT: GLOBAL ARTIFICIAL RETINA MARKET 72 TABLE 93 SECOND SIGHT: PRODUCTS/SERVICES OFFERED 74 TABLE 94 SECOND SIGHT: KEY DEVELOPMENTS 74 TABLE 95 PIXIUM VISION: PRODUCTS/SERVICES OFFERED 76 TABLE 96 OPTOBIONICS: PRODUCTS/SERVICES OFFERED 78 LIST OF FIGURES FIGURE 1 GLOBAL ARTIFICIAL RETINA MARKET STRUCTURE 14 FIGURE 2 BOTTOM-UP AND TOP-DOWN APPROACHES 20 FIGURE 3 MARKET DYNAMICS: GLOBAL ARTIFICIAL RETINA MARKET 22 FIGURE 4 DRIVERS: IMPACT ANALYSIS 24 FIGURE 5 RESTRAINTS: IMPACT ANALYSIS 25 FIGURE 6 VALUE CHAIN ANALYSIS: GLOBAL ARTIFICIAL RETINA MARKET 26 FIGURE 7 PORTER’S FIVE FORCES ANALYSIS: GLOBAL ARTIFICIAL RETINA MARKET 28 FIGURE 8 GLOBAL ARTIFICIAL RETINA MARKET, BY TYPE 2018 & 2025 (USD THOUSAND) 30 FIGURE 9 GLOBAL ARTIFICIAL RETINA MARKET, BY INDICATION 2018 & 2025 (USD THOUSAND) 33 FIGURE 10 GLOBAL ARTIFICIAL RETINA MARKET, BY END USER 2018 & 2025 (USD THOUSAND) 36 FIGURE 11 GLOBAL ARTIFICIAL RETINA MARKET SHARE, BY REGION 2018 & 2025 (USD THOUSAND) 38 FIGURE 12 AMERICAS: ARTIFICIAL RETINA MARKET, BY REGION, 2018 & 2025 (USD THOUSAND) 39 FIGURE 13 EUROPE: ARTIFICIAL RETINA MARKET, BY REGION, 2018 & 2025 (USD THOUSAND) 45 FIGURE 14 ASIA-PACIFIC: ARTIFICIAL RETINA MARKET, BY REGION, 2018 & 2025 (USD THOUSAND) 56 FIGURE 15 MIDDLE EAST & AFRICA: ARTIFICIAL RETINA MARKET, BY REGION, 2018 & 2025 (USD THOUSAND) 65 FIGURE 16 COMPETITOR DASHBOARD: GLOBAL ARTIFICIAL RETINA MARKET 71 FIGURE 17 BENCHMARKING OF MAJOR COMPETITORS 71 FIGURE 18 MAJOR STRATEGY ADOPTED BY KEY PLAYERS IN THE GLOBAL ARTIFICIAL RETINA MARKET 72 FIGURE 19 SECOND SIGHT: FINANCIAL OVERVIEW 73 FIGURE 20 SECOND SIGHT: SWOT ANALYSIS 75 FIGURE 21 PIXIUM VISION: SWOT ANALYSIS 77 FIGURE 22 OPTOBIONICS: SWOT ANALYSIS 79

Second Sight (US), Pixium Vision (France), and Optobionics (US)