Table of Content 1 Axitinib Market Definition and Overview 1.1 Objectives of the Study 1.2 Overview of Axitinib 1.3 Axitinib Market Scope and Market Size Estimation 1.4 Market Segmentation 1.4.1 Types of Axitinib 1.4.2 Applications of Axitinib 1.5 Market Exchange Rate 2 Research Method and Logic 2.1 Methodology 2.2 Research Data Source 3 Market Competition Analysis 3.1 Five Prime Therapeutics Market Performance Analysis 3.1.1 Five Prime Therapeutics Basic Information 3.1.2 Product and Service Analysis 3.1.3 Strategies for Company to Deal with the Impact of COVID-19 3.1.4 Five Prime Therapeutics Sales, Value, Price, Gross Margin 2016-2021 3.2 Bionomics Market Performance Analysis 3.2.1 Bionomics Basic Information 3.2.2 Product and Service Analysis 3.2.3 Strategies for Company to Deal with the Impact of COVID-19 3.2.4 Bionomics Sales, Value, Price, Gross Margin 2016-2021 3.3 Biocon Market Performance Analysis 3.3.1 Biocon Basic Information 3.3.2 Product and Service Analysis 3.3.3 Strategies for Company to Deal with the Impact of COVID-19 3.3.4 Biocon Sales, Value, Price, Gross Margin 2016-2021 3.4 Angstrom Pharmaceuticals Market Performance Analysis 3.4.1 Angstrom Pharmaceuticals Basic Information 3.4.2 Product and Service Analysis 3.4.3 Strategies for Company to Deal with the Impact of COVID-19 3.4.4 Angstrom Pharmaceuticals Sales, Value, Price, Gross Margin 2016-2021 3.5 Genentech Market Performance Analysis 3.5.1 Genentech Basic Information 3.5.2 Product and Service Analysis 3.5.3 Strategies for Company to Deal with the Impact of COVID-19 3.5.4 Genentech Sales, Value, Price, Gross Margin 2016-2021 3.6 CASI Pharmaceuticals Market Performance Analysis 3.6.1 CASI Pharmaceuticals Basic Information 3.6.2 Product and Service Analysis 3.6.3 Strategies for Company to Deal with the Impact of COVID-19 3.6.4 CASI Pharmaceuticals Sales, Value, Price, Gross Margin 2016-2021 3.7 Alnylam Pharmaceuticals Market Performance Analysis 3.7.1 Alnylam Pharmaceuticals Basic Information 3.7.2 Product and Service Analysis 3.7.3 Strategies for Company to Deal with the Impact of COVID-19 3.7.4 Alnylam Pharmaceuticals Sales, Value, Price, Gross Margin 2016-2021 3.8 Pfizer Market Performance Analysis 3.8.1 Pfizer Basic Information 3.8.2 Product and Service Analysis 3.8.3 Strategies for Company to Deal with the Impact of COVID-19 3.8.4 Pfizer Sales, Value, Price, Gross Margin 2016-2021 3.9 Celgene Corporation Market Performance Analysis 3.9.1 Celgene Corporation Basic Information 3.9.2 Product and Service Analysis 3.9.3 Strategies for Company to Deal with the Impact of COVID-19 3.9.4 Celgene Corporation Sales, Value, Price, Gross Margin 2016-2021 3.10 Amgen Market Performance Analysis 3.10.1 Amgen Basic Information 3.10.2 Product and Service Analysis 3.10.3 Strategies for Company to Deal with the Impact of COVID-19 3.10.4 Amgen Sales, Value, Price, Gross Margin 2016-2021 3.11 Fujifilm Kyowa Kirin Biologics Market Performance Analysis 3.11.1 Fujifilm Kyowa Kirin Biologics Basic Information 3.11.2 Product and Service Analysis 3.11.3 Strategies for Company to Deal with the Impact of COVID-19 3.11.4 Fujifilm Kyowa Kirin Biologics Sales, Value, Price, Gross Margin 2016-2021 3.12 Enzon Pharmaceuticals Market Performance Analysis 3.12.1 Enzon Pharmaceuticals Basic Information 3.12.2 Product and Service Analysis 3.12.3 Strategies for Company to Deal with the Impact of COVID-19 3.12.4 Enzon Pharmaceuticals Sales, Value, Price, Gross Margin 2016-2021 3.13 Allergan Market Performance Analysis 3.13.1 Allergan Basic Information 3.13.2 Product and Service Analysis 3.13.3 Strategies for Company to Deal with the Impact of COVID-19 3.13.4 Allergan Sales, Value, Price, Gross Margin 2016-2021 3.14 Acceleron Pharma Market Performance Analysis 3.14.1 Acceleron Pharma Basic Information 3.14.2 Product and Service Analysis 3.14.3 Strategies for Company to Deal with the Impact of COVID-19 3.14.4 Acceleron Pharma Sales, Value, Price, Gross Margin 2016-2021 4 Market Segment by Type, Historical Data and Market Forecasts 4.1 Global Axitinib Production and Value by Type 4.1.1 Global Axitinib Production by Type 2016-2021 4.1.2 Global Axitinib Market Value by Type 2016-2021 4.2 Global Axitinib Market Production, Value and Growth Rate by Type 2016-2021 4.2.1 Injection Market Production, Value and Growth Rate 4.2.2 Others Market Production, Value and Growth Rate 4.3 Global Axitinib Production and Value Forecast by Type 4.3.1 Global Axitinib Production Forecast by Type 2021-2026 4.3.2 Global Axitinib Market Value Forecast by Type 2021-2026 4.4 Global Axitinib Market Production, Value and Growth Rate by Type Forecast 2021-2026 4.4.1 Injection Market Production, Value and Growth Rate Forecast 4.4.2 Others Market Production, Value and Growth Rate Forecast 5 Market Segment by Application, Historical Data and Market Forecasts 5.1 Global Axitinib Consumption and Value by Application 5.1.1 Global Axitinib Consumption by Application 2016-2021 5.1.2 Global Axitinib Market Value by Application 2016-2021 5.2 Global Axitinib Market Consumption, Value and Growth Rate by Application 2016-2021 5.2.1 Renal Cancer Treatment Market Consumption, Value and Growth Rate 5.2.2 Others Market Consumption, Value and Growth Rate 5.3 Global Axitinib Consumption and Value Forecast by Application 5.3.1 Global Axitinib Consumption Forecast by Application 2021-2026 5.3.2 Global Axitinib Market Value Forecast by Application 2021-2026 5.4 Global Axitinib Market Consumption, Value and Growth Rate by Application Forecast 2021-2026 5.4.1 Renal Cancer Treatment Market Consumption, Value and Growth Rate Forecast 5.4.2 Others Market Consumption, Value and Growth Rate Forecast 6 Global Axitinib by Region, Historical Data and Market Forecasts 6.1 Global Axitinib Sales by Region 2016-2021 6.2 Global Axitinib Market Value by Region 2016-2021 6.3 Global Axitinib Market Sales, Value and Growth Rate by Region 2016-2021 6.3.1 North America 6.3.2 Europe 6.3.3 Asia Pacific 6.3.4 South America 6.3.5 Middle East and Africa 6.4 Global Axitinib Sales Forecast by Region 2021-2026 6.5 Global Axitinib Market Value Forecast by Region 2021-2026 6.6 Global Axitinib Market Sales, Value and Growth Rate Forecast by Region 2021-2026 6.6.1 North America 6.6.2 Europe 6.6.3 Asia Pacific 6.6.4 South America 6.6.5 Middle East and Africa 7 United State Market Size Analysis 2016-2026 7.1 United State Axitinib Value and Market Growth 2016-2021 7.2 United State Axitinib Sales and Market Growth 2016-2021 7.3 United State Axitinib Market Value Forecast 2021-2026 8 Canada Market Size Analysis 2016-2026 8.1 Canada Axitinib Value and Market Growth 2016-2021 8.2 Canada Axitinib Sales and Market Growth 2016-2021 8.3 Canada Axitinib Market Value Forecast 2021-2026 9 Germany Market Size Analysis 2016-2026 9.1 Germany Axitinib Value and Market Growth 2016-2021 9.2 Germany Axitinib Sales and Market Growth 2016-2021 9.3 Germany Axitinib Market Value Forecast 2021-2026 10 UK Market Size Analysis 2016-2026 10.1 UK Axitinib Value and Market Growth 2016-2021 10.2 UK Axitinib Sales and Market Growth 2016-2021 10.3 UK Axitinib Market Value Forecast 2021-2026 11 France Market Size Analysis 2016-2026 11.1 France Axitinib Value and Market Growth 2016-2021 11.2 France Axitinib Sales and Market Growth 2016-2021 11.3 France Axitinib Market Value Forecast 2021-2026 12 Italy Market Size Analysis 2016-2026 12.1 Italy Axitinib Value and Market Growth 2016-2021 12.2 Italy Axitinib Sales and Market Growth 2016-2021 12.3 Italy Axitinib Market Value Forecast 2021-2026 13 Spain Market Size Analysis 2016-2026 13.1 Spain Axitinib Value and Market Growth 2016-2021 13.2 Spain Axitinib Sales and Market Growth 2016-2021 13.3 Spain Axitinib Market Value Forecast 2021-2026 14 Russia Market Size Analysis 2016-2026 14.1 Russia Axitinib Value and Market Growth 2016-2021 14.2 Russia Axitinib Sales and Market Growth 2016-2021 14.3 Russia Axitinib Market Value Forecast 2021-2026 15 China Market Size Analysis 2016-2026 15.1 China Axitinib Value and Market Growth 2016-2021 15.2 China Axitinib Sales and Market Growth 2016-2021 15.3 China Axitinib Market Value Forecast 2021-2026 16 Japan Market Size Analysis 2016-2026 16.1 Japan Axitinib Value and Market Growth 2016-2021 16.2 Japan Axitinib Sales and Market Growth 2016-2021 16.3 Japan Axitinib Market Value Forecast 2021-2026 17 South Korea Market Size Analysis 2016-2026 17.1 South Korea Axitinib Value and Market Growth 2016-2021 17.2 South Korea Axitinib Sales and Market Growth 2016-2021 17.3 South Korea Axitinib Market Value Forecast 2021-2026 18 Australia Market Size Analysis 2016-2026 18.1 Australia Axitinib Value and Market Growth 2016-2021 18.2 Australia Axitinib Sales and Market Growth 2016-2021 18.3 Australia Axitinib Market Value Forecast 2021-2026 19 Thailand Market Size Analysis 2016-2026 19.1 Thailand Axitinib Value and Market Growth 2016-2021 19.2 Thailand Axitinib Sales and Market Growth 2016-2021 19.3 Thailand Axitinib Market Value Forecast 2021-2026 20 Brazil Market Size Analysis 2016-2026 20.1 Brazil Axitinib Value and Market Growth 2016-2021 20.2 Brazil Axitinib Sales and Market Growth 2016-2021 20.3 Brazil Axitinib Market Value Forecast 2021-2026 21 Argentina Market Size Analysis 2016-2026 21.1 Argentina Axitinib Value and Market Growth 2016-2021 21.2 Argentina Axitinib Sales and Market Growth 2016-2021 21.3 Argentina Axitinib Market Value Forecast 2021-2026 22 Chile Market Size Analysis 2016-2026 22.1 Chile Axitinib Value and Market Growth 2016-2021 22.2 Chile Axitinib Sales and Market Growth 2016-2021 22.3 Chile Axitinib Market Value Forecast 2021-2026 23 South Africa Market Size Analysis 2016-2026 23.1 South Africa Axitinib Value and Market Growth 2016-2021 23.2 South Africa Axitinib Sales and Market Growth 2016-2021 23.3 South Africa Axitinib Market Value Forecast 2021-2026 24 Egypt Market Size Analysis 2016-2026 24.1 Egypt Axitinib Value and Market Growth 2016-2021 24.2 Egypt Axitinib Sales and Market Growth 2016-2021 24.3 Egypt Axitinib Market Value Forecast 2021-2026 25 UAE Market Size Analysis 2016-2026 25.1 UAE Axitinib Value and Market Growth 2016-2021 25.2 UAE Axitinib Sales and Market Growth 2016-2021 25.3 UAE Axitinib Market Value Forecast 2021-2026 26 Saudi Arabia Market Size Analysis 2016-2026 26.1 Saudi Arabia Axitinib Value and Market Growth 2016-2021 26.2 Saudi Arabia Axitinib Sales and Market Growth 2016-2021 26.3 Saudi Arabia Axitinib Market Value Forecast 2021-2026 27 Market Dynamic Analysis and Development Suggestions 27.1 Market Drivers 27.2 Market Development Constraints 27.3 PEST Analysis 27.3.1 Political Factors 27.3.2 Economic Factors 27.3.3 Social Factors 27.3.4 Technological Factors 27.4 Industry Trends Under COVID-19 27.4.1 Risk Assessment on COVID-19 27.4.2 Assessment of the Overall Impact of COVID-19 on the Industry 27.4.3 Pre COVID-19 and Post COVID-19 Market Scenario 27.5 Market Entry Strategy Analysis 27.5.1 Market Definition 27.5.2 Client 27.5.3 Distribution Model 27.5.4 Product Messaging and Positioning 27.5.5 Price 27.6 Advice on Entering the Market

List of Tables and Figures Market Size Comparison Before and After the COVID-19 Outbreak of Major Company Global Axitinib Market Size in 2020 and 2026 Market Size Comparison Before and After the COVID-19 Outbreak of Major Countries Figure Global Axitinib Value (M USD) Segment by Type from 2016-2021 Figure Global Axitinib Market (M USD) Share by Types in 2020 Table Different Applications of Axitinib Figure Global Axitinib Value (M USD) Segment by Applications from 2016-2021 Figure Global Axitinib Market Share by Applications in 2020 Table Market Exchange Rate Table Five Prime Therapeutics Basic Information Table Product and Service Analysis Table Five Prime Therapeutics Sales, Value, Price, Gross Margin 2016-2021 Table Bionomics Basic Information Table Product and Service Analysis Table Bionomics Sales, Value, Price, Gross Margin 2016-2021 Table Biocon Basic Information Table Product and Service Analysis Table Biocon Sales, Value, Price, Gross Margin 2016-2021 Table Angstrom Pharmaceuticals Basic Information Table Product and Service Analysis Table Angstrom Pharmaceuticals Sales, Value, Price, Gross Margin 2016-2021 Table Genentech Basic Information Table Product and Service Analysis Table Genentech Sales, Value, Price, Gross Margin 2016-2021 Table CASI Pharmaceuticals Basic Information Table Product and Service Analysis Table CASI Pharmaceuticals Sales, Value, Price, Gross Margin 2016-2021 Table Alnylam Pharmaceuticals Basic Information Table Product and Service Analysis Table Alnylam Pharmaceuticals Sales, Value, Price, Gross Margin 2016-2021 Table Pfizer Basic Information Table Product and Service Analysis Table Pfizer Sales, Value, Price, Gross Margin 2016-2021 Table Celgene Corporation Basic Information Table Product and Service Analysis Table Celgene Corporation Sales, Value, Price, Gross Margin 2016-2021 Table Amgen Basic Information Table Product and Service Analysis Table Amgen Sales, Value, Price, Gross Margin 2016-2021 Table Fujifilm Kyowa Kirin Biologics Basic Information Table Product and Service Analysis Table Fujifilm Kyowa Kirin Biologics Sales, Value, Price, Gross Margin 2016-2021 Table Enzon Pharmaceuticals Basic Information Table Product and Service Analysis Table Enzon Pharmaceuticals Sales, Value, Price, Gross Margin 2016-2021 Table Allergan Basic Information Table Product and Service Analysis Table Allergan Sales, Value, Price, Gross Margin 2016-2021 Table Acceleron Pharma Basic Information Table Product and Service Analysis Table Acceleron Pharma Sales, Value, Price, Gross Margin 2016-2021 Table Global Axitinib Consumption by Type 2016-2021 Table Global Axitinib Consumption Share by Type 2016-2021 Table Global Axitinib Market Value (M USD) by Type 2016-2021 Table Global Axitinib Market Value Share by Type 2016-2021 Figure Global Axitinib Market Production and Growth Rate of Injection 2016-2021 Figure Global Axitinib Market Value and Growth Rate of Injection 2016-2021 Figure Global Axitinib Market Production and Growth Rate of Others 2016-2021 Figure Global Axitinib Market Value and Growth Rate of Others 2016-2021 Table Global Axitinib Consumption Forecast by Type 2021-2026 Table Global Axitinib Consumption Share Forecast by Type 2021-2026 Table Global Axitinib Market Value (M USD) Forecast by Type 2021-2026 Table Global Axitinib Market Value Share Forecast by Type 2021-2026 Figure Global Axitinib Market Production and Growth Rate of Injection Forecast 2021-2026 Figure Global Axitinib Market Value and Growth Rate of Injection Forecast 2021-2026 Figure Global Axitinib Market Production and Growth Rate of Others Forecast 2021-2026 Figure Global Axitinib Market Value and Growth Rate of Others Forecast 2021-2026 Table Global Axitinib Consumption by Application 2016-2021 Table Global Axitinib Consumption Share by Application 2016-2021 Table Global Axitinib Market Value (M USD) by Application 2016-2021 Table Global Axitinib Market Value Share by Application 2016-2021 Figure Global Axitinib Market Consumption and Growth Rate of Renal Cancer Treatment 2016-2021 Figure Global Axitinib Market Value and Growth Rate of Renal Cancer Treatment 2016-2021Figure Global Axitinib Market Consumption and Growth Rate of Others 2016-2021 Figure Global Axitinib Market Value and Growth Rate of Others 2016-2021Table Global Axitinib Consumption Forecast by Application 2021-2026 Table Global Axitinib Consumption Share Forecast by Application 2021-2026 Table Global Axitinib Market Value (M USD) Forecast by Application 2021-2026 Table Global Axitinib Market Value Share Forecast by Application 2021-2026 Figure Global Axitinib Market Consumption and Growth Rate of Renal Cancer Treatment Forecast 2021-2026 Figure Global Axitinib Market Value and Growth Rate of Renal Cancer Treatment Forecast 2021-2026 Figure Global Axitinib Market Consumption and Growth Rate of Others Forecast 2021-2026 Figure Global Axitinib Market Value and Growth Rate of Others Forecast 2021-2026 Table Global Axitinib Sales by Region 2016-2021 Table Global Axitinib Sales Share by Region 2016-2021 Table Global Axitinib Market Value (M USD) by Region 2016-2021 Table Global Axitinib Market Value Share by Region 2016-2021 Figure North America Axitinib Sales and Growth Rate 2016-2021 Figure North America Axitinib Market Value (M USD) and Growth Rate 2016-2021 Figure Europe Axitinib Sales and Growth Rate 2016-2021 Figure Europe Axitinib Market Value (M USD) and Growth Rate 2016-2021 Figure Asia Pacific Axitinib Sales and Growth Rate 2016-2021 Figure Asia Pacific Axitinib Market Value (M USD) and Growth Rate 2016-2021 Figure South America Axitinib Sales and Growth Rate 2016-2021 Figure South America Axitinib Market Value (M USD) and Growth Rate 2016-2021 Figure Middle East and Africa Axitinib Sales and Growth Rate 2016-2021 Figure Middle East and Africa Axitinib Market Value (M USD) and Growth Rate 2016-2021 Table Global Axitinib Sales Forecast by Region 2021-2026 Table Global Axitinib Sales Share Forecast by Region 2021-2026 Table Global Axitinib Market Value (M USD) Forecast by Region 2021-2026 Table Global Axitinib Market Value Share Forecast by Region 2021-2026 Figure North America Axitinib Sales and Growth Rate Forecast 2021-2026 Figure North America Axitinib Market Value (M USD) and Growth Rate Forecast 2021-2026 Figure Europe Axitinib Sales and Growth Rate Forecast 2021-2026 Figure Europe Axitinib Market Value (M USD) and Growth Rate Forecast 2021-2026 Figure Asia Pacific Axitinib Sales and Growth Rate Forecast 2021-2026 Figure Asia Pacific Axitinib Market Value (M USD) and Growth Rate Forecast 2021-2026 Figure South America Axitinib Sales and Growth Rate Forecast 2021-2026 Figure South America Axitinib Market Value (M USD) and Growth Rate Forecast 2021-2026 Figure Middle East and Africa Axitinib Sales and Growth Rate Forecast 2021-2026 Figure Middle East and Africa Axitinib Market Value (M USD) and Growth Rate Forecast 2021-2026 Figure United State Axitinib Value (M USD) and Market Growth 2016-2021 Figure United State Axitinib Sales and Market Growth 2016-2021 Figure United State Axitinib Market Value and Growth Rate Forecast 2021-2026 Figure Canada Axitinib Value (M USD) and Market Growth 2016-2021 Figure Canada Axitinib Sales and Market Growth 2016-2021 Figure Canada Axitinib Market Value and Growth Rate Forecast 2021-2026 Figure Germany Axitinib Value (M USD) and Market Growth 2016-2021 Figure Germany Axitinib Sales and Market Growth 2016-2021 Figure Germany Axitinib Market Value and Growth Rate Forecast 2021-2026 Figure UK Axitinib Value (M USD) and Market Growth 2016-2021 Figure UK Axitinib Sales and Market Growth 2016-2021 Figure UK Axitinib Market Value and Growth Rate Forecast 2021-2026 Figure France Axitinib Value (M USD) and Market Growth 2016-2021 Figure France Axitinib Sales and Market Growth 2016-2021 Figure France Axitinib Market Value and Growth Rate Forecast 2021-2026 Figure Italy Axitinib Value (M USD) and Market Growth 2016-2021 Figure Italy Axitinib Sales and Market Growth 2016-2021 Figure Italy Axitinib Market Value and Growth Rate Forecast 2021-2026 Figure Spain Axitinib Value (M USD) and Market Growth 2016-2021 Figure Spain Axitinib Sales and Market Growth 2016-2021 Figure Spain Axitinib Market Value and Growth Rate Forecast 2021-2026 Figure Russia Axitinib Value (M USD) and Market Growth 2016-2021 Figure Russia Axitinib Sales and Market Growth 2016-2021 Figure Russia Axitinib Market Value and Growth Rate Forecast 2021-2026 Figure China Axitinib Value (M USD) and Market Growth 2016-2021 Figure China Axitinib Sales and Market Growth 2016-2021 Figure China Axitinib Market Value and Growth Rate Forecast 2021-2026 Figure Japan Axitinib Value (M USD) and Market Growth 2016-2021 Figure Japan Axitinib Sales and Market Growth 2016-2021 Figure Japan Axitinib Market Value and Growth Rate Forecast 2021-2026 Figure South Korea Axitinib Value (M USD) and Market Growth 2016-2021 Figure South Korea Axitinib Sales and Market Growth 2016-2021 Figure South Korea Axitinib Market Value and Growth Rate Forecast 2021-2026 Figure Australia Axitinib Value (M USD) and Market Growth 2016-2021 Figure Australia Axitinib Sales and Market Growth 2016-2021 Figure Australia Axitinib Market Value and Growth Rate Forecast 2021-2026 Figure Thailand Axitinib Value (M USD) and Market Growth 2016-2021 Figure Thailand Axitinib Sales and Market Growth 2016-2021 Figure Thailand Axitinib Market Value and Growth Rate Forecast 2021-2026 Figure Brazil Axitinib Value (M USD) and Market Growth 2016-2021 Figure Brazil Axitinib Sales and Market Growth 2016-2021 Figure Brazil Axitinib Market Value and Growth Rate Forecast 2021-2026 Figure Argentina Axitinib Value (M USD) and Market Growth 2016-2021 Figure Argentina Axitinib Sales and Market Growth 2016-2021 Figure Argentina Axitinib Market Value and Growth Rate Forecast 2021-2026 Figure Chile Axitinib Value (M USD) and Market Growth 2016-2021 Figure Chile Axitinib Sales and Market Growth 2016-2021 Figure Chile Axitinib Market Value and Growth Rate Forecast 2021-2026 Figure South Africa Axitinib Value (M USD) and Market Growth 2016-2021 Figure South Africa Axitinib Sales and Market Growth 2016-2021 Figure South Africa Axitinib Market Value and Growth Rate Forecast 2021-2026 Figure Egypt Axitinib Value (M USD) and Market Growth 2016-2021 Figure Egypt Axitinib Sales and Market Growth 2016-2021 Figure Egypt Axitinib Market Value and Growth Rate Forecast 2021-2026 Figure UAE Axitinib Value (M USD) and Market Growth 2016-2021 Figure UAE Axitinib Sales and Market Growth 2016-2021 Figure UAE Axitinib Market Value and Growth Rate Forecast 2021-2026 Figure Saudi Arabia Axitinib Value (M USD) and Market Growth 2016-2021 Figure Saudi Arabia Axitinib Sales and Market Growth 2016-2021 Figure Saudi Arabia Axitinib Market Value and Growth Rate Forecast 2021-2026 Table Market Drivers Table Market Development Constraints Table PEST Analysis