Viral Vector and Plasmid DNA Manufacturing Market Size, Share, Growth, and Industry Analysis, By Type (Viral Vectors, Plasmid DNA), By Application (Cancers, Inherited Disorders, Viral Infections, Others), Regional Insights and Forecast to 2035

Viral Vector and Plasmid DNA Manufacturing Market Overview

The global Viral Vector and Plasmid DNA Manufacturing Market size estimated at USD 1797.61 million in 2026 and is projected to reach USD 33116.65 million by 2035, growing at a CAGR of 38.23% from 2026 to 2035.

The Viral Vector and Plasmid DNA Manufacturing Market is experiencing rapid expansion due to increasing demand for gene therapies, cell therapies, DNA vaccines, and advanced biologics. More than 3,000 gene therapy clinical trials are active globally, while over 2,000 cell therapy studies require reliable viral vector and plasmid DNA production. Adeno-associated virus (AAV), lentiviral vectors, adenoviral vectors, and plasmid DNA collectively account for over 85% of manufacturing demand across research and commercial applications. Manufacturing facilities have increased production capacity by more than 40% during the past five years, while automation adoption exceeds 55% in modern production facilities. 

The United States dominates the Viral Vector and Plasmid DNA Manufacturing Market through strong biotechnology infrastructure, extensive clinical research, and advanced manufacturing capabilities. The country hosts more than 45% of global gene therapy clinical trials and over 50% of commercial viral vector manufacturing facilities. More than 900 biotechnology companies are actively involved in cell and gene therapy development, supported by over 150 specialized GMP manufacturing sites. Adoption of single-use bioprocessing systems exceeds 70% among major manufacturers. 

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Key Findings

• Market Size & Growth: More than 3,000 active gene therapy clinical programs worldwide, over 2,000 cell therapy studies, and manufacturing capacity expanded by over 40% during the past five years.
• Key Market Driver: Increasing gene therapy adoption contributes more than 68% of manufacturing demand. AAV vectors represent nearly 42% of production requirements, plasmid DNA utilization has increased by approximately 37%, and GMP manufacturing demand exceeds 60% across advanced therapeutic development programs.
• Major Market Restraint: Manufacturing complexity affects approximately 58% of developers, batch failure rates range between 8% and 15%, validation activities extend production timelines by over 30%, and workforce shortages impact nearly 34% of manufacturing facilities.
• Emerging Trends: Single-use technologies have achieved adoption above 72%, automation integration exceeds 55%, continuous bioprocessing implementation has increased by 33%, and AI-assisted manufacturing optimization improves production efficiency by approximately 26%.
• Regional Leadership: North America accounts for approximately 46% of manufacturing activity, Europe contributes around 29%, Asia-Pacific exceeds 21%, while the Middle East & Africa and Latin America collectively represent approximately 4%.
• Competitive Landscape: Contract development and manufacturing organizations support nearly 62% of outsourced production, integrated manufacturers account for approximately 38%, facility expansion activities increased by 31%, and strategic collaborations rose by nearly 28%.
• Market Segmentation: Viral vector manufacturing contributes approximately 69% of total production demand, plasmid DNA manufacturing accounts for nearly 31%, commercial-scale manufacturing exceeds 44%, while clinical-stage manufacturing represents approximately 56% of operational capacity.
• Recent Development: Manufacturing facility expansions increased by approximately 32%, advanced bioreactor deployment rose by 27%, plasmid DNA process optimization improved yields by 24%, purification efficiency increased by 21%, and digital manufacturing implementation expanded by nearly 30%.

Viral Vector and Plasmid DNA Manufacturing Market Latest Trends

The Viral Vector and Plasmid DNA Manufacturing Market is evolving through advanced manufacturing technologies, improved purification systems, and increased outsourcing by biotechnology companies. Single-use bioreactors now represent more than 70% of newly installed manufacturing systems, reducing contamination risks by approximately 35%. Automated downstream purification has improved production consistency by nearly 28%, while closed-system manufacturing has reduced processing errors by over 22%. Demand for AAV and lentiviral vectors continues to account for over 65% of commercial manufacturing activities, supporting expanding gene therapy pipelines.

Another significant trend is the rapid growth of high-quality plasmid DNA production for mRNA vaccines, CRISPR applications, and next-generation gene editing technologies. More than 60% of new manufacturing investments focus on flexible GMP facilities capable of supporting multiple vector platforms. Digital quality monitoring has reduced deviation rates by approximately 20%, while continuous process monitoring has enhanced batch success by nearly 18%. The Viral Vector and Plasmid DNA Manufacturing Market Forecast, Viral Vector and Plasmid DNA Manufacturing Market Analysis, and Viral Vector and Plasmid DNA Manufacturing Market Opportunities increasingly emphasize scalable manufacturing, supply chain resilience, and faster clinical production to meet growing global demand.

Viral Vector and Plasmid DNA Manufacturing Market Dynamics

DRIVER

"Growing Demand for Gene and Cell Therapy Manufacturing"

The strongest growth driver for the Viral Vector and Plasmid DNA Manufacturing Market is the increasing global pipeline of gene and cell therapies. More than 45% of ongoing advanced therapy clinical trials require AAV vectors, while lentiviral vectors account for approximately 23% of investigational programs. Over 900 biotechnology companies are actively developing advanced therapies requiring GMP-grade viral vectors and plasmid DNA. 

RESTRAINTS

"Complex Manufacturing Processes and Regulatory Requirements"

Manufacturing complexity remains one of the most significant restraints affecting the Viral Vector and Plasmid DNA Manufacturing Market. Viral vector production involves multiple purification, validation, and quality-control stages, increasing operational complexity. Approximately 58% of manufacturers identify process consistency as a major challenge, while batch rejection rates range between 8% and 15%. 

OPPORTUNITY

"Expansion of Personalized Medicine and Next-Generation Gene Editing"

Personalized medicine is creating substantial opportunities for the Viral Vector and Plasmid DNA Manufacturing Market. More than 60% of precision medicine development programs now incorporate viral vectors or plasmid DNA during research or manufacturing stages. Demand for plasmid DNA supporting CRISPR-based therapies has increased by approximately 40% over recent years, while customized manufacturing projects have expanded by nearly 32%.

CHALLENGE

"Limited Manufacturing Capacity and Supply Chain Constraints"

Limited large-scale manufacturing capacity remains a major challenge for the Viral Vector and Plasmid DNA Manufacturing Market despite increasing investments. Facility utilization frequently exceeds 85%, creating production bottlenecks for commercial and late-stage clinical programs. Delivery timelines have extended by approximately 20% because of shortages of specialized raw materials, single-use bioprocessing components, and high-quality plasmid DNA intermediates. 

Viral Vector and Plasmid DNA Manufacturing Market Segmentation

The Viral Vector and Plasmid DNA Manufacturing Market is segmented by type and application to address the growing requirements of gene therapy, cell therapy, DNA vaccines, and advanced biologics manufacturing. By type, the market consists of Viral Vectors and Plasmid DNA, both serving essential roles in therapeutic development and commercial production. By application, the market supports Gene Therapy, Cell Therapy, DNA Vaccines, Research Institutes, Biotechnology Companies, Pharmaceutical Companies, and Clinical Manufacturing Facilities. Increasing demand for GMP production, automation. 

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BY TYPE

Viral Vectors: Viral vectors represent the largest segment of the Viral Vector and Plasmid DNA Manufacturing Market because they are the primary delivery systems for gene therapies, engineered cell therapies, and numerous advanced biologic products. Adeno-associated virus (AAV), lentiviral vectors, adenoviral vectors, retroviral vectors, and herpes simplex virus vectors collectively account for more than 69% of manufacturing demand across the industry. AAV vectors alone contribute approximately 42% of commercial viral vector production due to their safety profile and high efficiency in gene transfer. Lentiviral vectors account for nearly 23% of production activities because they are widely used in CAR-T cell therapy and stem cell modification. More than 3,000 active gene therapy clinical studies worldwide require reliable viral vector manufacturing, while over 65% of commercial advanced therapy products depend on viral delivery technologies. 

Plasmid DNA: Plasmid DNA manufacturing has become an essential segment of the Viral Vector and Plasmid DNA Manufacturing Market because plasmids serve as critical starting materials for viral vector production, DNA vaccines, gene editing technologies, and mRNA manufacturing. This segment accounts for approximately 31% of total manufacturing demand and continues to expand as precision medicine applications increase worldwide. More than 60% of plasmid DNA manufacturing supports viral vector production, while approximately 25% is utilized for gene editing platforms such as CRISPR technologies. High-quality GMP-grade plasmid DNA is required for nearly all commercial gene therapy manufacturing programs, with purity standards commonly exceeding 98%. Manufacturing efficiency has improved by approximately 24% through optimized bacterial fermentation, advanced chromatography purification. 

BY APPLICATION

Cancers: Cancer represents the largest application segment in the Viral Vector and Plasmid DNA Manufacturing Market because viral vectors and plasmid DNA are extensively used in gene therapies, CAR-T cell therapies, oncolytic virus development, and cancer vaccine research. More than 40% of advanced therapy clinical programs are directed toward oncology indications, making cancer the primary demand generator for viral vector manufacturing. Over 1,500 oncology-focused clinical studies utilize viral vectors or plasmid DNA during therapeutic development. Lentiviral vectors are widely employed in engineered T-cell therapies, while adeno-associated virus vectors are increasingly investigated for targeted cancer treatment approaches. Manufacturing facilities supporting oncology programs frequently operate at utilization rates exceeding 80% because of growing commercial and clinical demand. 

Inherited Disorders: Inherited disorders represent one of the fastest-expanding applications within the Viral Vector and Plasmid DNA Manufacturing Market because gene replacement therapies rely heavily on high-quality viral vectors and plasmid DNA. More than 30% of global gene therapy clinical programs target inherited genetic disorders, including hemophilia, muscular dystrophy, retinal diseases, metabolic disorders, and rare neurological conditions. Adeno-associated virus vectors account for approximately 70% of manufacturing demand in this application because of their favorable safety profile and efficient gene delivery. More than 500 rare disease development programs currently require commercial-grade vector manufacturing. 

Viral Infections: Viral infections constitute an important application segment of the Viral Vector and Plasmid DNA Manufacturing Market because plasmid DNA and viral vectors support vaccine development, antiviral gene therapies, and infectious disease research. DNA vaccines, viral vector vaccines, and therapeutic gene delivery systems require highly purified manufacturing processes to ensure product quality and regulatory compliance. More than 25% of plasmid DNA manufacturing capacity supports infectious disease programs. Viral vector vaccine manufacturing utilizes approximately 45% of available commercial adenoviral production capacity.

Others: The "Others" application segment includes neurological disorders, cardiovascular diseases, ophthalmic diseases, autoimmune disorders, regenerative medicine, and research applications that require viral vector and plasmid DNA manufacturing. Together these applications account for approximately 20% of total manufacturing demand and continue expanding as advanced therapies move into new disease areas. More than 600 investigational therapies outside oncology and inherited diseases currently utilize viral vectors during development. Ophthalmology and neurological programs collectively represent nearly 45% of this application category because adeno-associated virus vectors demonstrate efficient tissue targeting.

Viral Vector and Plasmid DNA Manufacturing Market Regional Outlook

The Viral Vector and Plasmid DNA Manufacturing Market demonstrates strong regional diversification driven by biotechnology investments, advanced therapy development, manufacturing infrastructure, and regulatory support. North America leads the global market with approximately 46% market share owing to its concentration of gene therapy developers and GMP manufacturing facilities. Europe follows with nearly 29% market share, supported by extensive pharmaceutical research and expanding cell and gene therapy production. 

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NORTH AMERICA

North America holds the largest position in the Viral Vector and Plasmid DNA Manufacturing Market with approximately 46% of global market share, supported by an advanced biotechnology ecosystem, extensive research infrastructure, and high adoption of gene and cell therapies. The region contains more than 50% of the world's commercial viral vector manufacturing facilities and over 45% of active gene therapy clinical programs. More than 900 biotechnology companies across the region actively develop advanced therapies requiring viral vectors and plasmid DNA. Approximately 70% of manufacturing facilities utilize single-use bioprocessing technologies that improve operational flexibility and reduce contamination risks by nearly 35%. Automated downstream processing has improved production consistency by approximately 28%, while digital quality monitoring has lowered batch deviations by around 20%. Contract manufacturing organizations account for nearly 62% of outsourced production activities, enabling rapid commercialization of emerging therapies. More than 80% of commercial-scale production facilities continue expanding manufacturing capacity to meet increasing demand for oncology, rare disease, and gene editing applications. Strong regulatory oversight, continuous facility modernization, skilled workforce availability, and increasing investments in precision medicine further strengthen regional manufacturing capabilities. 

EUROPE

Europe represents approximately 29% of the Viral Vector and Plasmid DNA Manufacturing Market, making it the second-largest regional contributor to global manufacturing activities. The region benefits from strong pharmaceutical manufacturing expertise, advanced academic research, and increasing commercialization of advanced therapy medicinal products. More than 700 biotechnology organizations across Europe participate in gene therapy, cell therapy, and plasmid DNA development. Approximately 60% of regional manufacturing facilities have implemented automated process control systems, improving production efficiency by nearly 24%. Single-use manufacturing platforms are installed in more than 65% of newly commissioned facilities, enhancing operational flexibility and reducing contamination risks. Europe also supports over 30% of ongoing rare disease gene therapy development programs. Advanced purification technologies have increased vector recovery efficiency by around 26%, while digital manufacturing systems have reduced production variability by approximately 18%. Contract manufacturing continues to expand as biotechnology companies increasingly outsource GMP production to specialized facilities. 

GERMANY Viral Vector and Plasmid DNA Manufacturing Market

Germany accounts for approximately 8% of the global Viral Vector and Plasmid DNA Manufacturing Market and remains one of Europe's leading biotechnology manufacturing centers. The country's advanced pharmaceutical sector, highly skilled workforce, and extensive research collaborations support continuous expansion of viral vector and plasmid DNA production. More than 120 biotechnology companies in Germany are actively engaged in advanced therapy development and manufacturing activities. Automated manufacturing systems are implemented in nearly 68% of specialized production facilities, improving operational efficiency by approximately 25%. Single-use bioreactor adoption exceeds 60%, reducing contamination risks while improving production flexibility. Germany also supports numerous research institutes focused on gene editing, regenerative medicine, and rare disease therapies. Approximately 35% of domestic production supports oncology-related therapeutic development, while inherited disease programs account for nearly 28%. 

UNITED KINGDOM Viral Vector and Plasmid DNA Manufacturing Market

The United Kingdom contributes approximately 6% of the global Viral Vector and Plasmid DNA Manufacturing Market and continues strengthening its position through biotechnology innovation and advanced therapy research. More than 90 biotechnology companies across the country participate in viral vector production, plasmid DNA manufacturing, and gene therapy development. Around 65% of manufacturing facilities utilize automated production systems that improve process efficiency by approximately 23%. Adoption of single-use manufacturing technologies exceeds 62%, supporting flexible GMP production for clinical and commercial applications. Nearly 40% of manufacturing demand originates from oncology and immunotherapy programs, while inherited genetic disorders contribute approximately 30%. Research institutions and biotechnology companies continue expanding collaborations to accelerate clinical development and manufacturing innovation. Advanced purification technologies have improved vector recovery by approximately 24%. 

ASIA-PACIFIC

Asia-Pacific accounts for approximately 21% of the global Viral Vector and Plasmid DNA Manufacturing Market and is emerging as the fastest-expanding regional manufacturing hub due to increasing biotechnology investments, expanding pharmaceutical production, and rising numbers of gene therapy clinical programs. More than 650 biotechnology companies across Asia-Pacific are involved in advanced biologics, viral vector development, and plasmid DNA manufacturing. Over 320 dedicated GMP manufacturing facilities support research, clinical, and commercial production throughout the region. Approximately 48% of newly established manufacturing sites utilize single-use bioreactor technologies, while automation adoption has exceeded 52%, improving manufacturing productivity by nearly 27%. More than 35% of regional manufacturing projects focus on gene therapy, while cell therapy applications account for approximately 30% of production activities. Demand for plasmid DNA has increased by over 34% because of expanding genome editing and DNA vaccine research. Process optimization technologies have improved vector recovery by approximately 24%. 

JAPAN Viral Vector and Plasmid DNA Manufacturing Market

Japan represents approximately 5% of the global Viral Vector and Plasmid DNA Manufacturing Market and maintains a strong position through advanced biotechnology research, precision manufacturing capabilities, and supportive regulatory initiatives for regenerative medicine. More than 110 biotechnology companies are actively involved in gene therapy, cell therapy, and plasmid DNA development across the country. Approximately 62% of specialized manufacturing facilities have implemented automated production technologies, improving manufacturing efficiency by nearly 22%. Single-use bioprocessing systems are utilized in over 58% of production facilities, helping reduce contamination risks and increasing manufacturing flexibility. Around 36% of domestic manufacturing supports oncology therapies, while inherited genetic disorders account for nearly 27% of production demand. Japan continues expanding research into genome editing, viral vector optimization, and regenerative medicine applications. Advanced analytical testing has improved batch consistency by approximately 18%. 

CHINA Viral Vector and Plasmid DNA Manufacturing Market

China contributes approximately 10% of the global Viral Vector and Plasmid DNA Manufacturing Market and has become one of the largest manufacturing centers in Asia because of extensive biotechnology investments, expanding GMP facilities, and rapidly growing advanced therapy research. More than 280 biotechnology companies participate in viral vector and plasmid DNA manufacturing activities throughout the country. Approximately 55% of manufacturing facilities have adopted automated production systems, increasing manufacturing productivity by nearly 26%. Single-use manufacturing platforms are installed in over 50% of production sites, supporting flexible commercial-scale manufacturing. Nearly 40% of production demand originates from oncology research, while inherited disease therapies account for approximately 25%. More than 120 advanced therapy development programs require commercial-grade viral vectors and plasmid DNA manufacturing. Process optimization has improved vector recovery efficiency by approximately 25%, while digital quality systems have lowered production deviations by nearly 20%. 

MIDDLE EAST & AFRICA

The Middle East & Africa accounts for approximately 2% of the global Viral Vector and Plasmid DNA Manufacturing Market and continues to develop steadily through increasing biotechnology investments, healthcare modernization, and growing participation in advanced therapy research. More than 90 biotechnology organizations and research institutions across the region are actively involved in gene therapy, vaccine development, and molecular medicine projects. Approximately 35% of biotechnology facilities have implemented modern GMP manufacturing practices, while automation adoption has reached nearly 30%, improving operational efficiency by approximately 18%. Viral vector demand is increasing due to expanding infectious disease research, oncology programs, and regenerative medicine initiatives. More than 45% of regional manufacturing activities support clinical research applications, while approximately 28% focus on vaccine development and plasmid DNA production. Investments in biotechnology infrastructure have increased manufacturing capacity by nearly 22%, while advanced purification technologies have improved product consistency by approximately 17%. 

List of Key Viral Vector and Plasmid DNA Manufacturing Market Companies

• Merck KGaA
• Lonza
• FUJIFILM Diosynth Biotechnologies U.S.A., Inc.
• Cobra Biologics Ltd.
• Brammer Bio
• Waisman Biomanufacturing
• Genezen
• YPOSKESI
• Advanced BioScience Laboratories, Inc. (ABL, Inc.)
• Novasep Holding S.A.S
• ATVIO Biotech Ltd.

Top Two Companies with Highest Share

• Lonza: Holds approximately 17% market share, supported by extensive GMP manufacturing capacity, integrated viral vector production platforms, and a production success rate exceeding 95% across commercial and clinical manufacturing programs.
• Merck KGaA: Accounts for approximately 15% market share, driven by strong plasmid DNA manufacturing capabilities, advanced bioprocess technologies, and participation in more than 20% of outsourced advanced therapy manufacturing projects.

Investment Analysis and Opportunities

The Viral Vector and Plasmid DNA Manufacturing Market continues attracting significant investment because global demand for gene therapy, cell therapy, and genome editing technologies continues to increase. More than 65% of biotechnology investors are prioritizing manufacturing infrastructure capable of supporting commercial-scale viral vector production. Approximately 58% of newly announced manufacturing projects involve modular GMP facilities designed for flexible production of multiple vector platforms. Automation investments have increased by nearly 35%, allowing manufacturers to improve batch consistency and reduce operational deviations by approximately 22%. 

Emerging opportunities continue to expand as personalized medicine, CRISPR-based therapies, DNA vaccines, and regenerative medicine require scalable viral vector and plasmid DNA manufacturing. More than 40% of investment activity is directed toward expanding plasmid DNA production capacity because demand from gene editing programs continues to rise. Advanced purification technologies have improved manufacturing yields by approximately 25%, while continuous bioprocessing has increased production efficiency by nearly 23%. Around 48% of contract development and manufacturing organizations are expanding dedicated viral vector production suites to accommodate increasing commercial demand. Academic collaborations account for approximately 30% of technology transfer activities supporting new manufacturing processes. 

New Products Development

New product development within the Viral Vector and Plasmid DNA Manufacturing Market is centered on improving manufacturing efficiency, increasing vector yield, and supporting next-generation therapeutic platforms. More than 55% of newly introduced manufacturing technologies focus on high-yield viral vector production systems capable of supporting multiple therapeutic applications. Advanced suspension cell culture platforms have improved production efficiency by approximately 27%, while optimized plasmid DNA fermentation technologies have increased productivity by nearly 24%. 

Manufacturers are also introducing integrated digital manufacturing solutions, AI-assisted quality monitoring, and flexible modular production systems designed to support commercial-scale manufacturing. Approximately 45% of newly developed manufacturing platforms are optimized for adeno-associated virus production, while lentiviral vector technologies account for nearly 30% of recent product innovations. Improvements in chromatography systems have enhanced purification efficiency by approximately 22%, and closed-system manufacturing has reduced contamination risks by nearly 35%. More than 40% of product development activities are directed toward scalable plasmid DNA manufacturing technologies supporting CRISPR gene editing. 

Five Recent Developments

• Lonza:  expanded its viral vector manufacturing capabilities by increasing single-use bioprocess integration across multiple GMP production suites. The expansion improved manufacturing flexibility by approximately 28%, increased batch processing capacity by nearly 24%, and enhanced digital quality monitoring. 

• Merck KGaA:  introduced enhanced plasmid DNA manufacturing technologies featuring optimized fermentation and purification workflows. The upgraded manufacturing platform improved plasmid recovery efficiency by approximately 26%, reduced processing time by nearly 21%, and increased overall batch consistency by around 20%. 

• FUJIFILM Diosynth Biotechnologies:  expanded commercial viral vector production through additional modular manufacturing capacity designed for clinical and commercial supply. Automated production technologies were implemented across more than 60% of the expanded facility, improving manufacturing productivity by approximately 27% and lowering operational variability by nearly 18%.

• Genezen : strengthened its lentiviral vector manufacturing platform through advanced process optimization and improved analytical testing capabilities. The upgraded manufacturing workflow increased vector yield by approximately 23%, enhanced purification efficiency by nearly 22%. 

• Novasep Holding S.A.S:  expanded downstream purification capabilities by incorporating advanced chromatography technologies and automated quality monitoring systems. Manufacturing efficiency improved by approximately 25%, purification consistency increased by nearly 21%. 

Report Coverage of Viral Vector and Plasmid DNA Manufacturing Market

The Viral Vector and Plasmid DNA Manufacturing Market report provides comprehensive analysis of manufacturing technologies, production platforms, application segments, regional developments, competitive landscape, investment opportunities, and technological advancements shaping the industry. The report evaluates Viral Vectors and Plasmid DNA manufacturing across multiple therapeutic applications including cancers, inherited disorders, viral infections, and other advanced therapy indications. Approximately 69% of manufacturing demand originates from viral vectors, while plasmid DNA contributes nearly 31% of production activities. North America represents approximately 46% of global market share, Europe accounts for nearly 29%, Asia-Pacific contributes around 21%, and the remaining 4% is distributed across Latin America and the Middle East & Africa. The report also analyzes manufacturing trends such as single-use bioprocessing, automation. 

The report further examines production capacity expansion, contract manufacturing activities, technological innovation, regulatory developments, and strategic investments influencing the Viral Vector and Plasmid DNA Manufacturing Market. It evaluates manufacturing performance improvements including approximately 28% higher production efficiency through automated processing, around 25% improvement in purification technologies, and nearly 20% reduction in manufacturing deviations through digital monitoring systems. The study includes detailed segmentation by type, application, and regional outlook while profiling major manufacturers and assessing competitive positioning based on manufacturing capabilities, technological expertise, and production scalability. It also highlights opportunities generated by precision medicine, gene editing technologies, regenerative medicine, DNA vaccines, and commercial gene therapy manufacturing. The report is designed to support biotechnology companies, pharmaceutical manufacturers, contract development and manufacturing organizations, investors, suppliers, and healthcare stakeholders by providing actionable market insights, percentage-based performance indicators, industry trends, and manufacturing developments without relying on revenue-based analysis.